cAMP-responsive Element Modulator α (CREMα) trans-Represses the Transmembrane Glycoprotein CD8 and Contributes to the Generation of CD3(+)CD4(−)CD8(−) T Cells in Health and Disease

T cell receptor-αβ(+) CD3(+)CD4(−)CD8(−) “double-negative” T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus and autoimmune lymphoproliferative syndrome. In both disorders, double-negative T cells infiltrate tissues, induce immunoglobulin production, and secr...

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Autors principals: Hedrich, Christian M., Rauen, Thomas, Crispin, Jose C., Koga, Tomohiro, Ioannidis, Christina, Zajdel, Melissa, Kyttaris, Vasileios C., Tsokos, George C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Gene Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814780/
https://ncbi.nlm.nih.gov/pubmed/24047902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508655
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