cAMP-responsive Element Modulator (CREM)α Protein Signaling Mediates Epigenetic Remodeling of the Human Interleukin-2 Gene: IMPLICATIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS

IL-2 is a key cytokine during proliferation and activation of T lymphocytes and functions as an auto- and paracrine growth factor. Regardless of activating effects on T lymphocytes, the absence of IL-2 has been linked to the development of autoimmune pathology in mice and humans. Systemic lupus eryt...

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Bibliographische Detailangaben
Hauptverfasser: Hedrich, Christian M., Rauen, Thomas, Tsokos, George C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234875/
https://ncbi.nlm.nih.gov/pubmed/21976679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.299339
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