A Novel Intronic cAMP Response Element Modulator (CREM) Promoter Is Regulated by Activator Protein-1 (AP-1) and Accounts for Altered Activation-induced CREM Expression in T Cells from Patients with Systemic Lupus Erythematosus

The transcriptional repressor cAMP response element modulator (CREM) α has important roles in normal T cell physiology and contributes to aberrant T cell function in patients with systemic lupus erythematosus (SLE). Recently, we characterized a specificity protein-1-dependent promoter located upstre...

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Detalhes bibliográficos
Main Authors: Rauen, Thomas, Benedyk, Konrad, Juang, Yuang-Taung, Kerkhoff, Claus, Kyttaris, Vasileios C., Roth, Johannes, Tsokos, George C., Tenbrock, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173235/
https://ncbi.nlm.nih.gov/pubmed/21757709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.245811
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