Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV

Systemic lupus erythematosus (SLE) T cells express high levels of cAMP response element modulator (CREM) that binds to the IL-2 promoter and represses the transcription of the IL-2 gene. This study was designed to identify pathways that lead to increased binding of CREM to the IL-2 promoter in SLE T...

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Main Authors: Juang, Yuang-Taung, Wang, Ying, Solomou, Elena E., Li, Yansong, Mawrin, Christian, Tenbrock, Klaus, Kyttaris, Vasileios C., Tsokos, George C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1070410/
https://ncbi.nlm.nih.gov/pubmed/15841182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522854
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