Transcriptional Activation of the cAMP-responsive Modulator Promoter in Human T Cells Is Regulated by Protein Phosphatase 2A-mediated Dephosphorylation of SP-1 and Reflects Disease Activity in Patients with Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with numerous abnormalities recorded at the cellular, molecular, and genetic level. Expression of the basic leucine zipper transcription factor cAMP-responsive element modulator (CREM)α was reported to be abnormally increased in T ce...

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Detalhes bibliográficos
Main Authors: Juang, Yuang-Taung, Rauen, Thomas, Wang, Ying, Ichinose, Kunihiro, Benedyk, Konrad, Tenbrock, Klaus, Tsokos, George C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023474/
https://ncbi.nlm.nih.gov/pubmed/21097497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166785
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