Immunization with Apical Membrane Antigen 1 Confers Sterile Infection-Blocking Immunity against Plasmodium Sporozoite Challenge in a Rodent Model

Apical membrane antigen 1 (AMA-1) is a leading blood-stage malaria vaccine candidate. Consistent with a key role in erythrocytic invasion, AMA-1-specific antibodies have been implicated in AMA-1-induced protective immunity. AMA-1 is also expressed in sporozoites and in mature liver schizonts where i...

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Main Authors: Schussek, Sophie, Trieu, Angela, Apte, Simon H., Sidney, John, Sette, Alessandro, Doolan, Denise L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Microbial Immunity and Vaccines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811765/
https://ncbi.nlm.nih.gov/pubmed/23836827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00544-13
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