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Minimal Role for the Circumsporozoite Protein in the Induction of Sterile Immunity by Vaccination with Live Rodent Malaria Sporozoites

Immunization with live Plasmodium sporozoites under chloroquine prophylaxis (Spz plus CQ) induces sterile immunity against sporozoite challenge in rodents and, more importantly, in humans. Full protection is obtained with substantially fewer parasites than with the classic immunization with radiatio...

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Detalhes bibliográficos
Main Authors: Mauduit, Marjorie, Tewari, Rita, Depinay, Nadya, Kayibanda, Michèle, Lallemand, Eliette, Chavatte, Jean-Marc, Snounou, Georges, Rénia, Laurent, Grüner, Anne Charlotte
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863544/
https://ncbi.nlm.nih.gov/pubmed/20194600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01415-09
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