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Minimal Role for the Circumsporozoite Protein in the Induction of Sterile Immunity by Vaccination with Live Rodent Malaria Sporozoites

Immunization with live Plasmodium sporozoites under chloroquine prophylaxis (Spz plus CQ) induces sterile immunity against sporozoite challenge in rodents and, more importantly, in humans. Full protection is obtained with substantially fewer parasites than with the classic immunization with radiatio...

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Main Authors: Mauduit, Marjorie, Tewari, Rita, Depinay, Nadya, Kayibanda, Michèle, Lallemand, Eliette, Chavatte, Jean-Marc, Snounou, Georges, Rénia, Laurent, Grüner, Anne Charlotte
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863544/
https://ncbi.nlm.nih.gov/pubmed/20194600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01415-09
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