Mutations of the ompK36 Porin Gene and Promoter Impact Responses of Sequence Type 258, KPC-2-Producing Klebsiella pneumoniae Strains to Doripenem and Doripenem-Colistin

Doripenem-colistin exerts synergy against some, but not all, Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains in vitro. We determined if doripenem MICs and/or ompK36 porin gene mutations impacted the responses of 23 sequence type 258 (ST258), KPC-2-producing strains to the c...

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Detalhes bibliográficos
Main Authors: Clancy, Cornelius J., Chen, Liang, Hong, Jae H., Cheng, Shaoji, Hao, Binghua, Shields, Ryan K., Farrell, Annie N., Doi, Yohei, Zhao, Yanan, Perlin, David S., Kreiswirth, Barry N., Nguyen, M. Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811244/
https://ncbi.nlm.nih.gov/pubmed/23939888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01069-13
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