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Mutations of the ompK36 Porin Gene and Promoter Impact Responses of Sequence Type 258, KPC-2-Producing Klebsiella pneumoniae Strains to Doripenem and Doripenem-Colistin

Doripenem-colistin exerts synergy against some, but not all, Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains in vitro. We determined if doripenem MICs and/or ompK36 porin gene mutations impacted the responses of 23 sequence type 258 (ST258), KPC-2-producing strains to the c...

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書誌詳細
主要な著者: Clancy, Cornelius J., Chen, Liang, Hong, Jae H., Cheng, Shaoji, Hao, Binghua, Shields, Ryan K., Farrell, Annie N., Doi, Yohei, Zhao, Yanan, Perlin, David S., Kreiswirth, Barry N., Nguyen, M. Hong
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811244/
https://ncbi.nlm.nih.gov/pubmed/23939888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01069-13
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