Doripenem, Gentamicin, and Colistin, Alone and in Combinations, against Gentamicin-Susceptible, KPC-Producing Klebsiella pneumoniae Strains with Various ompK36 Genotypes

Gentamicin doses of 2 and 10 μg/ml were bactericidal against 64% and 100%, respectively, of gentamicin-susceptible KPC-2-producing Klebsiella pneumoniae strains. Treatment with the combination of doripenem (8 μg/ml) plus colistin (2 μg/ml) was inferior to treatment with gentamicin (2 μg/ml), doripen...

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Main Authors: Clancy, Cornelius J., Hao, Binghua, Shields, Ryan K., Chen, Liang, Perlin, David S., Kreiswirth, Barry N., Nguyen, M. Hong
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068457/
https://ncbi.nlm.nih.gov/pubmed/24566172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01949-13
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