Mutations of the ompK36 Porin Gene and Promoter Impact Responses of Sequence Type 258, KPC-2-Producing Klebsiella pneumoniae Strains to Doripenem and Doripenem-Colistin

Doripenem-colistin exerts synergy against some, but not all, Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains in vitro. We determined if doripenem MICs and/or ompK36 porin gene mutations impacted the responses of 23 sequence type 258 (ST258), KPC-2-producing strains to the c...

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Bibliografiset tiedot
Päätekijät: Clancy, Cornelius J., Chen, Liang, Hong, Jae H., Cheng, Shaoji, Hao, Binghua, Shields, Ryan K., Farrell, Annie N., Doi, Yohei, Zhao, Yanan, Perlin, David S., Kreiswirth, Barry N., Nguyen, M. Hong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2013
Aiheet:
Mechanisms of Resistance
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811244/
https://ncbi.nlm.nih.gov/pubmed/23939888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01069-13
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