12/15-Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy

BACKGROUND: Increased mitogen-activated protein kinase (MAPK) phosphorylation has been detected in peripheral nerve of human subjects and animal models with diabetes as well as high-glucose exposed human Schwann cells, and have been implicated in diabetic peripheral neuropathy. In our recent studies...

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Auteurs principaux: Stavniichuk, Roman, Obrosov, Alexander A., Drel, Viktor R., Nadler, Jerry L., Obrosova, Irina G., Yorek, Mark A.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808974/
https://ncbi.nlm.nih.gov/pubmed/24175152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/jdm.2013.33015
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