INTERPLAY OF SORBITOL PATHWAY OF GLUCOSE METABOLISM, 12/15-LIPOXYGENASE, AND MITOGEN-ACTIVATED PROTEIN KINASES IN THE PATHOGENESIS OF DIABETIC PERIPHERAL NEUROPATHY

The interactions among multiple pathogenetic mechanisms of diabetic peripheral neuropathy largely remain unexplored. Increased activity of aldose reductase, the first enzyme of the sorbitol pathway, leads to accumulation of cytosolic Ca(++), essentially required for 12/15-lipoxygenase activation. Th...

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Bibliographic Details
Main Authors: Stavniichuk, Roman, Shevalye, Hanna, Hirooka, Hiroko, Nadler, Jerry L., Obrosova, Irina G.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288510/
https://ncbi.nlm.nih.gov/pubmed/22285226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.01.015
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