BAICALEIN ALLEVIATES DIABETIC PERIPHERAL NEUROPATHY THROUGH INHIBITION OF OXIDATIVE-NITROSATIVE STRESS AND p38 MAPK ACTIVATION

With consideration of multifactorial etiology of diabetic peripheral neuropathy, an ideal drug or drug combination should target at least several key pathogenetic mechanisms. The flavonoid baicalein (5,6,7-trihydroxyflavone) has been reported to counteract sorbitol accumulation, activation of 12/15-...

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Detalhes bibliográficos
Main Authors: Stavniichuk, Roman, Drel, Viktor R., Shevalye, Hanna, Maksimchyk, Yury, Kuchmerovska, Tamara M., Nadler, Jerry L., Obrosova, Irina G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215942/
https://ncbi.nlm.nih.gov/pubmed/21515260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.04.002
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