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POLY(ADP-RIBOSE) POLYMERASE-1 (PARP-1) GENE DEFICIENCY ALLEVIATES DIABETIC KIDNEY DISEASE
Poly(ADP-ribose)polymerase (PARP) inhibitors prevent or alleviate diabetic nephropathy. This study evaluated the role for PARP-1 in diabetic kidney disease using the PARP-1-deficient mouse. PARP-1−/− and the wild-type (129S1/SvImJ) mice were made diabetic with streptozotocin, and were maintained for...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4217200/ https://ncbi.nlm.nih.gov/pubmed/20621183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2010.07.004 |
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