POLY(ADP-RIBOSE) POLYMERASE-1 (PARP-1) GENE DEFICIENCY ALLEVIATES DIABETIC KIDNEY DISEASE

Poly(ADP-ribose)polymerase (PARP) inhibitors prevent or alleviate diabetic nephropathy. This study evaluated the role for PARP-1 in diabetic kidney disease using the PARP-1-deficient mouse. PARP-1−/− and the wild-type (129S1/SvImJ) mice were made diabetic with streptozotocin, and were maintained for...

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Bibliographic Details
Main Authors: Shevalye, Hanna, Maksimchyk, Yury, Watcho, Pierre, Obrosova, Irina G.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217200/
https://ncbi.nlm.nih.gov/pubmed/20621183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2010.07.004
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