Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses

Poly(ADP-ribosylation) of acceptor proteins is an epigenetic modification involved in DNA strand break repair, recombination and transcription. Here we provide evidence for the involvement of poly(ADP-ribose) polymerase-1 (Parp-1) in antibody responses. Parp-1(−/−) mice had increased numbers of T ce...

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Autori principali: Ambrose, Helen E, Willimott, Shaun, Beswick, Richard W, Dantzer, Françoise, de Murcia, Josiane Ménissier, Yelamos, José, Wagner, Simon D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2009
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691783/
https://ncbi.nlm.nih.gov/pubmed/18778284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2008.02921.x
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