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Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice
PARP-1-deficient mice display a severe defect in the base excision repair pathway leading to radiosensitivity and genomic instability. They are protected against necrosis induced by massive oxidative stress in various inflammatory processes. Mice lacking p53 are highly predisposed to malignancy resu...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2001
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125506/ https://ncbi.nlm.nih.gov/pubmed/11432840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.13.3535 |
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