Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice

PARP-1-deficient mice display a severe defect in the base excision repair pathway leading to radiosensitivity and genomic instability. They are protected against necrosis induced by massive oxidative stress in various inflammatory processes. Mice lacking p53 are highly predisposed to malignancy resu...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Conde, Carmen, Mark, Manuel, Oliver, F.Javier, Huber, Aline, de Murcia, Gilbert, Ménissier-de Murcia, Josiane
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125506/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11432840/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.13.3535
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