The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

Poly(ADP-ribose) polymerase (EC 2.4.2.30) is a zinc-binding protein that specifically binds to a DNA strand break in a zinc-dependent manner. We describe here the cloning and expression in Escherichia coli of a cDNA fragment encoding the two putative zinc fingers (FI and FII) domain of the human pol...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Gradwohl, G, Ménissier de Murcia, J M, Molinete, M, Simonin, F, Koken, M, Hoeijmakers, J H, de Murcia, G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53819/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2109322/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.8.2990
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