The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

Poly(ADP-ribose) polymerase (EC 2.4.2.30) is a zinc-binding protein that specifically binds to a DNA strand break in a zinc-dependent manner. We describe here the cloning and expression in Escherichia coli of a cDNA fragment encoding the two putative zinc fingers (FI and FII) domain of the human pol...

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Main Authors: Gradwohl, G, Ménissier de Murcia, J M, Molinete, M, Simonin, F, Koken, M, Hoeijmakers, J H, de Murcia, G
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC53819/
https://ncbi.nlm.nih.gov/pubmed/2109322
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