Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice

PARP-1-deficient mice display a severe defect in the base excision repair pathway leading to radiosensitivity and genomic instability. They are protected against necrosis induced by massive oxidative stress in various inflammatory processes. Mice lacking p53 are highly predisposed to malignancy resu...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Conde, Carmen, Mark, Manuel, Oliver, F.Javier, Huber, Aline, de Murcia, Gilbert, Ménissier-de Murcia, Josiane
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2001
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125506/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11432840/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.13.3535
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