Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice

Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play...

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Main Authors: Piskunova, Tatiana S., Yurova, Maria N., Ovsyannikov, Anton I., Semenchenko, Anna V., Zabezhinski, Mark A., Popovich, Irina G., Wang, Zhao-Qi, Anisimov, Vladimir N.
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672038/
https://ncbi.nlm.nih.gov/pubmed/19415146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/754190
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