BAICALEIN ALLEVIATES DIABETIC PERIPHERAL NEUROPATHY THROUGH INHIBITION OF OXIDATIVE-NITROSATIVE STRESS AND p38 MAPK ACTIVATION

With consideration of multifactorial etiology of diabetic peripheral neuropathy, an ideal drug or drug combination should target at least several key pathogenetic mechanisms. The flavonoid baicalein (5,6,7-trihydroxyflavone) has been reported to counteract sorbitol accumulation, activation of 12/15-...

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Autori principali: Stavniichuk, Roman, Drel, Viktor R., Shevalye, Hanna, Maksimchyk, Yury, Kuchmerovska, Tamara M., Nadler, Jerry L., Obrosova, Irina G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215942/
https://ncbi.nlm.nih.gov/pubmed/21515260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.04.002
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