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Toward the structure of presenilin/γ-secretase and homologs
Presenilin is the catalytic component of the γ-secretase complex, a membrane-embedded aspartyl protease that plays a central role in biology and in the pathogenesis of Alzheimer's disease. Upon assembly with its three protein cofactors (nicastrin, Aph-1 and Pen-2), presenilin undergoes autoprot...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3801419/ https://ncbi.nlm.nih.gov/pubmed/24099007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2013.04.015 |
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