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Toward the structure of presenilin/γ-secretase and homologs

Presenilin is the catalytic component of the γ-secretase complex, a membrane-embedded aspartyl protease that plays a central role in biology and in the pathogenesis of Alzheimer's disease. Upon assembly with its three protein cofactors (nicastrin, Aph-1 and Pen-2), presenilin undergoes autoprot...

詳細記述

保存先:
書誌詳細
第一著者: Wolfe, Michael S.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801419/
https://ncbi.nlm.nih.gov/pubmed/24099007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2013.04.015
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