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Mycobacterium tuberculosis but not non-virulent mycobacteria inhibit IFN-β and AIM2-inflammasome dependent IL-1β production via their ESX-1 secretion system
Mycobacterium tuberculosis (Mtb) extracellular DNA (eDNA) gains access to the host cell cytosol via the ESX-1 secretion system. It is puzzling that this eDNA of Mtb does not induce activation of the AIM2-inflammasome since AIM2 recognizes cytosolic DNA. Here we show that non-virulent mycobacteria su...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3799997/ https://ncbi.nlm.nih.gov/pubmed/23997220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301331 |
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