Mycobacterium tuberculosis but not non-virulent mycobacteria inhibit IFN-β and AIM2-inflammasome dependent IL-1β production via their ESX-1 secretion system

Mycobacterium tuberculosis (Mtb) extracellular DNA (eDNA) gains access to the host cell cytosol via the ESX-1 secretion system. It is puzzling that this eDNA of Mtb does not induce activation of the AIM2-inflammasome since AIM2 recognizes cytosolic DNA. Here we show that non-virulent mycobacteria su...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Shah, Swati, Bohsali, Amro, Ahlbrand, Sarah E., Srinivasan, Lalitha, Rathinam, Vijay A. K., Vogel, Stefanie N., Fitzgerald, Katherine A., Sutterwala, Fayyaz S., Briken, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799997/
https://ncbi.nlm.nih.gov/pubmed/23997220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301331
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados