Mycobacterium tuberculosis Infection of Dendritic Cells Leads to Partially Caspase-1/11-Independent IL-1β and IL-18 Secretion but Not to Pyroptosis

BACKGROUND: Interleukin-1β (IL-1β) is important for host resistance against Mycobacterium tuberculosis (Mtb) infections. The response of the dendritic cell inflammasome during Mtb infections has not been investigated in detail. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that Mtb infection of bone...

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Detalhes bibliográficos
Main Authors: Abdalla, Hana, Srinivasan, Lalitha, Shah, Swati, Mayer-Barber, Katrin D., Sher, Alan, Sutterwala, Fayyaz S., Briken, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404059/
https://ncbi.nlm.nih.gov/pubmed/22911706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040722
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