Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

To investigate the respective contributions of TLR versus IL-1R mediated signals in MyD88 dependent control of Mycobacterium tuberculosis, we compared the outcome of M. tuberculosis infection in MyD88, TRIF/MyD88, IL-1R1, and IL-1β-deficient mice. All four strains displayed acute mortality with high...

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Detalhes bibliográficos
Main Authors: Mayer-Barber, Katrin D., Barber, Daniel L., Shenderov, Kevin, White, Sandra D., Wilson, Mark S., Cheever, Allen, Kugler, David, Hieny, Sara, Caspar, Patricia, Núñez, Gabriel, Schlueter, Dirk, Flavell, Richard A., Sutterwala, Fayyaz S., Sher, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420351/
https://ncbi.nlm.nih.gov/pubmed/20200276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0904189
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