Mycobacterium tuberculosis but not non-virulent mycobacteria inhibit IFN-β and AIM2-inflammasome dependent IL-1β production via their ESX-1 secretion system

Mycobacterium tuberculosis (Mtb) extracellular DNA (eDNA) gains access to the host cell cytosol via the ESX-1 secretion system. It is puzzling that this eDNA of Mtb does not induce activation of the AIM2-inflammasome since AIM2 recognizes cytosolic DNA. Here we show that non-virulent mycobacteria su...

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Bibliografiska uppgifter
Huvudupphovsmän: Shah, Swati, Bohsali, Amro, Ahlbrand, Sarah E., Srinivasan, Lalitha, Rathinam, Vijay A. K., Vogel, Stefanie N., Fitzgerald, Katherine A., Sutterwala, Fayyaz S., Briken, Volker
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799997/
https://ncbi.nlm.nih.gov/pubmed/23997220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301331
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