Structure activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism

The structure activity relationships of N-(3-acyloxy-2-benzylpropyl)-N′-4-[(methylsulfonylamino)benzyl] thioureas, which represent simplified RTX-based vanilloids, were investigated by varying the distances between the four principal pharmacophores and assessing binding and antagonistic activity on...

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Autors principals: Bhondwe, Rahul S., Kang, Dong Wook, Kim, Myeong Seop, Kim, Ho Shin, Park, Seul-gi, Son, Karam, Choi, Sun, Lang-Kuhs, Krystle A., Pavlyukovets, Vladimir A., Pearce, Larry V., Blumberg, Peter M., Lee, Jeewoo
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799871/
https://ncbi.nlm.nih.gov/pubmed/22546668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.034
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