The SAR analysis of TRPV1 agonists with the α-methylated B-region

A series of TRPV1 agonists with amide, reverse amide, and thiourea groups in the B-region and their corresponding α-methylated analogues were investigated. Whereas the α–methylation of the amide B-region enhanced the binding affinities and potencies as agonists, that of the reverse amide and thioure...

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Detalhes bibliográficos
Main Authors: Cho, Yongsung, Kim, Myeong Seop, Kim, Ho Shin, Ann, Ji Hyae, Lee, Jiyoun, Pearce, Larry V., Pavlyukovets, Vladimir A., Morgan, Matthew A., Blumberg, Peter M., Lee, Jeewoo
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799874/
https://ncbi.nlm.nih.gov/pubmed/22796184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.06.059
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