Halogenation of 4-Hydroxy/Amino-3-methoxyphenyl Acetamide TRPV1 Agonists Showed Enhanced Antagonism to Capsaicin

As an extension of our analysis of the effect of halogenation on thiourea TRPV1 agonists, we have now modified selected 4-hydroxy(or 4-amino)-3-methoxyphenyl acetamide TRPV1 agonists by 5- or 6-halogenation on the aromatic A-region and evaluated them for potency for TRPV1 binding and regulation and...

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Hlavní autoři: Kang, Dong Wook, Kim, Yong Soo, Lim, Kwang Su, Kim, Myeong Seop, Lee, Jeewoo, Pearce, Larry V., Pavlyukovets, Vladimir A., Tao, Andy K., Lang-Kuhs, Krystle A., Blumberg, Peter M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420354/
https://ncbi.nlm.nih.gov/pubmed/20937561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.09.001
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