2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure–activity relationships in the B and C-regions

On the basis of the previous lead N-4-t-butylbenzyl 2-(3-fluoro-4-methylsulfonylaminophenyl) propanamide (3) as a potent TRPV1 antagonist, structure–activity relationships for the B (propanamide part) and C-region (4-t-butylbenzyl part) have been investigated for rTRPV1 in CHO cells. The B-region wa...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Sun, Wei, Liu, Keliang, Ryu, HyungChul, Kang, Dong Wook, Kim, Yong Soo, Kim, Myeong Seop, Cho, Yongsung, Bhondwe, Rahul S., Thorat, Shivaji A., Kim, Ho Shin, Pearce, Larry V., Pavlyukovets, Vladimir A., Tran, Richard, Morgan, Matthew A., Lazar, Jozsef, Ryder, Christopher B., Toth, Attila, Blumberg, Peter M., Lee, Jeewoo
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988731/
https://ncbi.nlm.nih.gov/pubmed/22227463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.12.014
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