2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure–activity relationships in the B and C-regions

On the basis of the previous lead N-4-t-butylbenzyl 2-(3-fluoro-4-methylsulfonylaminophenyl) propanamide (3) as a potent TRPV1 antagonist, structure–activity relationships for the B (propanamide part) and C-region (4-t-butylbenzyl part) have been investigated for rTRPV1 in CHO cells. The B-region wa...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem
Main Authors: Sun, Wei, Liu, Keliang, Ryu, HyungChul, Kang, Dong Wook, Kim, Yong Soo, Kim, Myeong Seop, Cho, Yongsung, Bhondwe, Rahul S., Thorat, Shivaji A., Kim, Ho Shin, Pearce, Larry V., Pavlyukovets, Vladimir A., Tran, Richard, Morgan, Matthew A., Lazar, Jozsef, Ryder, Christopher B., Toth, Attila, Blumberg, Peter M., Lee, Jeewoo
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988731/
https://ncbi.nlm.nih.gov/pubmed/22227463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.12.014
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