Structure activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism

The structure activity relationships of N-(3-acyloxy-2-benzylpropyl)-N′-4-[(methylsulfonylamino)benzyl] thioureas, which represent simplified RTX-based vanilloids, were investigated by varying the distances between the four principal pharmacophores and assessing binding and antagonistic activity on...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Bhondwe, Rahul S., Kang, Dong Wook, Kim, Myeong Seop, Kim, Ho Shin, Park, Seul-gi, Son, Karam, Choi, Sun, Lang-Kuhs, Krystle A., Pavlyukovets, Vladimir A., Pearce, Larry V., Blumberg, Peter M., Lee, Jeewoo
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799871/
https://ncbi.nlm.nih.gov/pubmed/22546668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.034
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados