Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues

BACKGROUND AND PURPOSE: 4-Phenylbutyric acid (4-PBA) is a chemical chaperone that eliminates the accumulation of unfolded proteins in the endoplasmic reticulum (ER). However, its chaperoning ability is often weak and unable to attenuate the unfolded protein response (UPR) in vitro or in vivo. To dev...

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Detalhes bibliográficos
Main Authors: Zhang, Hui, Nakajima, Shotaro, Kato, Hironori, Gu, Liubao, Yoshitomi, Tatsuya, Nagai, Kaoru, Shinmori, Hideyuki, Kokubo, Susumu, Kitamura, Masanori
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799596/
https://ncbi.nlm.nih.gov/pubmed/23869584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12306
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