Targeting the IRE1α/XBP1 and ATF6 Arms of the Unfolded Protein Response Enhances VEGF Blockade to Prevent Retinal and Choroidal Neovascularization

Although anti-vascular endothelial growth factor (VEGF) treatments reduce pathological neovascularization in the eye and in tumors, the regression is often not sustainable or is incomplete. We investigated whether vascular endothelial cells circumvent anti-VEGF therapies by activating the unfolded p...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Liu, Li, Qi, Xiaoping, Chen, Zhijuan, Shaw, Lynn, Cai, Jun, Smith, Layton H., Grant, Maria B., Boulton, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620403/
https://ncbi.nlm.nih.gov/pubmed/23395094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.12.020
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados