Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues

BACKGROUND AND PURPOSE: 4-Phenylbutyric acid (4-PBA) is a chemical chaperone that eliminates the accumulation of unfolded proteins in the endoplasmic reticulum (ER). However, its chaperoning ability is often weak and unable to attenuate the unfolded protein response (UPR) in vitro or in vivo. To dev...

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Autores principales: Zhang, Hui, Nakajima, Shotaro, Kato, Hironori, Gu, Liubao, Yoshitomi, Tatsuya, Nagai, Kaoru, Shinmori, Hideyuki, Kokubo, Susumu, Kitamura, Masanori
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799596/
https://ncbi.nlm.nih.gov/pubmed/23869584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12306
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