Selective Abrogation of BiP/GRP78 Blunts Activation of NF-κB through the ATF6 Branch of the UPR: Involvement of C/EBPβ and mTOR-Dependent Dephosphorylation of Akt

Subtilase cytotoxin (SubAB) that selectively cleaves BiP/GRP78 triggers the unfolded protein response (UPR) and protects mice from endotoxic lethality and collagen arthritis. We found that pretreatment of cells with SubAB suppressed tumor necrosis alpha (TNF-α)-induced activation of NF-κB and NF-κB-...

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Hoofdauteurs: Nakajima, Shotaro, Hiramatsu, Nobuhiko, Hayakawa, Kunihiro, Saito, Yukinori, Kato, Hironori, Huang, Tao, Yao, Jian, Paton, Adrienne W., Paton, James C., Kitamura, Masanori
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2011
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126329/
https://ncbi.nlm.nih.gov/pubmed/21300786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00939-10
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