Regulation of PERK Signaling and Leukemic Cell Survival by a Novel Cytosolic Isoform of the UPR Regulator GRP78/BiP

The unfolded protein response (UPR) is an evolutionarily conserved mechanism to allow cells to adapt to stress targeting the endoplasmic reticulum (ER). Induction of ER chaperone GRP78/BiP increases protein folding capacity; as such it represents a major survival arm of UPR. Considering the central...

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Bibliografiska uppgifter
Huvudupphovsmän: Ni, Min, Zhou, Hui, Wey, Shiuan, Baumeister, Peter, Lee, Amy S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2009
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729930/
https://ncbi.nlm.nih.gov/pubmed/19718440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006868
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