Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues

BACKGROUND AND PURPOSE: 4-Phenylbutyric acid (4-PBA) is a chemical chaperone that eliminates the accumulation of unfolded proteins in the endoplasmic reticulum (ER). However, its chaperoning ability is often weak and unable to attenuate the unfolded protein response (UPR) in vitro or in vivo. To dev...

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Hlavní autoři: Zhang, Hui, Nakajima, Shotaro, Kato, Hironori, Gu, Liubao, Yoshitomi, Tatsuya, Nagai, Kaoru, Shinmori, Hideyuki, Kokubo, Susumu, Kitamura, Masanori
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
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Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799596/
https://ncbi.nlm.nih.gov/pubmed/23869584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12306
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