Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues

BACKGROUND AND PURPOSE: 4-Phenylbutyric acid (4-PBA) is a chemical chaperone that eliminates the accumulation of unfolded proteins in the endoplasmic reticulum (ER). However, its chaperoning ability is often weak and unable to attenuate the unfolded protein response (UPR) in vitro or in vivo. To dev...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhang, Hui, Nakajima, Shotaro, Kato, Hironori, Gu, Liubao, Yoshitomi, Tatsuya, Nagai, Kaoru, Shinmori, Hideyuki, Kokubo, Susumu, Kitamura, Masanori
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2013
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799596/
https://ncbi.nlm.nih.gov/pubmed/23869584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12306
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