Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3

BACKGROUND AND PURPOSE: Aberrant activation of STAT3 is frequently encountered and promotes proliferation, survival, metastasis and angiogenesis in hepatocellular carcinoma (HCC). Here, we have investigated whether emodin mediates its effect through interference with the STAT3 activation pathway in...

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Bibliographic Details
Main Authors: Subramaniam, Aruljothi, Shanmugam, Muthu K, Ong, Tina H, Li, Feng, Perumal, Ekambaram, Chen, Luxi, Vali, Shireen, Abbasi, Taher, Kapoor, Shweta, Ahn, Kwang Seok, Kumar, Alan Prem, Hui, Kam M, Sethi, Gautam
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2013
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799595/
https://ncbi.nlm.nih.gov/pubmed/23848338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12302
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