Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

BACKGROUND AND PURPOSE: Activation of pro-inflammatory transcription factors NF-κB and signal transducer and activator of transcription 3 (STAT3) is one of the major contributors to both pathogenesis and chemoresistance in multiple myeloma (MM), which results in high mortality rate. Thus, in the pre...

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Autors principals: Kannaiyan, Radhamani, Hay, Hui Sin, Rajendran, Peramaiyan, Li, Feng, Shanmugam, Muthu K, Vali, Shireen, Abbasi, Taher, Kapoor, Shweta, Sharma, Ashish, Kumar, Alan Prem, Chng, Wee-Joo, Sethi, Gautam
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2011
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221104/
https://ncbi.nlm.nih.gov/pubmed/21506956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01449.x
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