Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

BACKGROUND: Increasing evidence indicates that the interaction between the CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in the process of metastasis that accounts for more than 90% of cancer-related deaths. Thus, novel agents that can downregulate the CXCR4/CXCL12 axis have the...

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Main Authors: Manu, Kanjoormana Aryan, Shanmugam, Muthu K, Rajendran, Peramaiyan, Li, Feng, Ramachandran, Lalitha, Hay, Hui Sin, Kannaiyan, Radhamani, Swamy, Shivananju Nanjunda, Vali, Shireen, Kapoor, Shweta, Ramesh, Bhargavi, Bist, Pradeep, Koay, Evelyn S, Lim, Lina HK, Ahn, Kwang Seok, Kumar, Alan Prem, Sethi, Gautam
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175200/
https://ncbi.nlm.nih.gov/pubmed/21880153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-107
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