Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma

Accumulating evidence(s) indicate that CXCL12-CXCR4 signaling cascade plays an important role in the process of invasion and metastasis that accounts for more than 80% of deaths in hepatocellular carcinoma (HCC) patients. Thus, identification of novel agents that can downregulate CXCR4 expression an...

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Autori principali: Manu, Kanjoormana Aryan, Shanmugam, Muthu K., Ong, Tina H., Subramaniam, Aruljothi, Siveen, Kodappully Sivaraman, Perumal, Ekambaram, Samy, Ramar Perumal, Bist, Pradeep, Lim, Lina H. K., Kumar, Alan Prem, Hui, Kam M., Sethi, Gautam
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589458/
https://ncbi.nlm.nih.gov/pubmed/23472074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057015
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