HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis

In women, estrogen deficiency after menopause frequently accelerates osteoclastic bone resorption, leading to osteoporosis, the most common skeletal disorder. However, mechanisms underlying osteoporosis resulting from estrogen deficiency remain largely unknown. Here we show that in bone-resorbing os...

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Hlavní autoři: Miyauchi, Yoshiteru, Sato, Yuiko, Kobayashi, Tami, Yoshida, Shigeyuki, Mori, Tomoaki, Kanagawa, Hiroya, Katsuyama, Eri, Fujie, Atsuhiro, Hao, Wu, Miyamoto, Kana, Tando, Toshimi, Morioka, Hideo, Matsumoto, Morio, Chambon, Pierre, Johnson, Randall S., Kato, Shigeaki, Toyama, Yoshiaki, Miyamoto, Takeshi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799362/
https://ncbi.nlm.nih.gov/pubmed/24023068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308755110
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