HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis

In women, estrogen deficiency after menopause frequently accelerates osteoclastic bone resorption, leading to osteoporosis, the most common skeletal disorder. However, mechanisms underlying osteoporosis resulting from estrogen deficiency remain largely unknown. Here we show that in bone-resorbing os...

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Detalles Bibliográficos
Autores principales: Miyauchi, Yoshiteru, Sato, Yuiko, Kobayashi, Tami, Yoshida, Shigeyuki, Mori, Tomoaki, Kanagawa, Hiroya, Katsuyama, Eri, Fujie, Atsuhiro, Hao, Wu, Miyamoto, Kana, Tando, Toshimi, Morioka, Hideo, Matsumoto, Morio, Chambon, Pierre, Johnson, Randall S., Kato, Shigeaki, Toyama, Yoshiaki, Miyamoto, Takeshi
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799362/
https://ncbi.nlm.nih.gov/pubmed/24023068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308755110
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